ORCHID · Project Overview
ORCHID
UC Berkeley · UCSF · Sheri Eckert Foundation
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ORCHID

The evidence that unlocks reimbursement for psychedelic care.

Project Overview

UC Berkeley · UCSF · Sheri Eckert Foundation

02 Why this matters

Elliot Marseille
Psychedelic care has shown real promise. But without evidence on costs and outcomes, it remains out of reach for most people. Health payers need to understand how this care performs in the real world — and ORCHID is designed to generate exactly that evidence.

With your support, we have a rare opportunity to make psychedelic care accessible to everyone, not just those who can afford it.
Elliot Marseille, DrPH, MPPDirector, Collaborative for the Economics of Psychedelics

03 The reality

Psychedelic care works.
But millions can’t access it.

Millions are suffering, current treatments often fall short, and psychedelic care remains out of reach without coverage.

The scale

280M+

people worldwide live with depression

World Health Organization

What clinical trials show

67%

of treatment-resistant depression patients responded to psilocybin

Johns Hopkins

2 / 3

patients don’t achieve remission with their first treatment*

Cleveland Clinic Journal of Medicine

71%

PTSD remission rate with MDMA-assisted therapy in Phase 3 trials

UCSF

Care that works, legal pathways that exist — yet most people pay $2,000–$5,000 out-of-pocket, and payers won’t cover what they can’t evaluate.

*From their first treatment option

04 The missing piece

One question is blocking access for millions

“Does psychedelic care reduce healthcare costs and improve outcomes in the real world?”

Here’s why asking this question in the state-regulated programs provides the answers we need:

FDA Clinical Trials

Where evidence comes from today

  • Not real-world
  • Controlled conditions
  • Indicate efficacy, but not cost-effectiveness
  • Small, diagnosis-specific

FDA-Regulated Care

The pharmaceutical pathway

  • Not yet available
  • Cost-effectiveness data years away
  • Access may be locked to approved diagnoses — reimbursement will be too
  • Cost-prohibitive until payers cover it

State-Regulated Programs

Where ORCHID looks

  • Real-world and available now
  • Live at scale — 20,000+ served
  • Open to all adults 21+
  • Lower cost than the FDA pathway
The state-regulated programs let us evaluate the health economics of psychedelic care today.

05 Introducing ORCHID — the first study of its kind

The first study to track people before and after psychedelic care, link their experience to real medical records, and show whether it actually reduces health-system costs.

What we expect to rise: wellbeing, preventive care use, and quality of life.

What we expect to fall: crisis visits, hospitalizations, and total health-system costs.

First

First study linking psilocybin services to real medical claims.

Real-world

Real populations, not clinical-trial cohorts.

Timely

Preliminary results in 24 months; full evidence in 42.

06 How it works

Two studies. Real-world evidence.

ORCHID ILooking back

Results in ~24 months
  • ~1,500 people who received psilocybin care 12+ months ago
  • Recruited through our relationships with facilitators, service centers, and electronic health record providers
  • Tracks ER visits, hospitalizations, prescriptions, behavioral health care, primary care, and more

ORCHID IILooking forward

Complete in ~42 months
  • In partnership with the UCSF CANOPY Project in Robin Carhart-Harris’ lab — 300+ sign-ups already
  • People enrolled as they enter care
  • Wellbeing and health outcomes tracked through 6 months after their experience

A platform built for the whole field

ORCHID works across provider types — wherever consent can be obtained and a service date identified — letting us assess the health economics of transformative experiences.

State-regulated · our focus Generic ketamine therapy Ibogaine therapy, in trials or abroad Anywhere consent + a service date exist

07 Impact

ORCHID unlocks three pathways to access

The evidence ORCHID generates is the key that opens many doors to reimbursement — simultaneously.

01

State-Funded Access

Near-term public investment

Data like this strengthens the case for adopting and resourcing state-regulated programs. New Mexico has already committed $630,000 to subsidize psilocybin treatment for low-income and rural residents.

02

Employer Health Plans

Already available — waiting on data

Employers can already choose to cover state-regulated psychedelic services through Enthea. ORCHID gives companies the real-world outcomes and cost data they need to evaluate, expand, and sustain coverage.

03

Insurance Coverage

The long game

Insurers cover treatments when real-world data shows reduced costs and improved outcomes. ORCHID will provide supporting evidence for coverage of FDA-regulated care.

08 The stakes

This is the moment that determines access for millions.

If ORCHID succeeds

We unlock

  • Coverage comes sooner — and could extend across both state and FDA-regulated care
  • State funding for psychedelic care
  • Access beyond early adopters
  • Legitimacy for state-regulated programs
  • Access for millions

Without ORCHID

We risk

  • Reimbursement flowing only through the pharmaceutical pathway
  • State-regulated services left without a viable route to coverage
  • State-regulated systems stagnating
  • Millions missing access to effective care
Boutique careSystem-supported care
Accessible carePrivilege for the few

09 The team behind ORCHID

Health economists, trial leaders, and the people who built the field.

Elliot Marseille
Elliot Marseille, DrPH, MPP Director of CEP · Principal, Health Strategies International
Stefano Bertozzi
Stefano Bertozzi, MD-PhD Professor of Health Policy & Management, UC Berkeley School of Public Health
Robin Carhart-Harris
Robin Carhart-Harris, PhD Professor, UCSF · Founder of the Carhart-Harris Lab
Will Lucas
Will Lucas Clinical Research Coordinator, Weill Institute for Neurosciences
Jim Kahn
Jim Kahn, MD, MPH Emeritus Professor of Health Policy, Epidemiology & Global Health, UCSF
Nathan Howard
Nathan Howard Executive Director, Sheri Eckert Foundation
Advisory board
Tyler Norris
Tyler Norris, MDiv Advisor on community health, wellbeing & social impact
Aaron Loehr
Aaron Loehr Board Chair, Mission to Live · ED, Better Community Health
David Bronner
David Bronner Cosmic Engagement Officer, Dr. Bronner’s
Tamar Todd
Tamar Todd Lecturer, Berkeley Law · Psychedelics law & drug policy expert
Britt Rollins
Britt Rollins Co-Founder, National Psychedelics Association
Bob Jesse
Bob Jesse Founder, Council on Spiritual Practices
Adie Rae
Adie Rae, PhD Co-Director, Open Psychedelic Evaluation Nexus (OPEN)
A collaboration between Sheri Eckert Foundation UC Berkeley
CEP mark
CEPCollaborative for the Economics of Psychedelics

10 Investment

Fund the shift

$1.79MILLION

Total philanthropic investment over 3.5 years

Why philanthropy?

No drug company will fund this. No commercial pathway exists. Without this evidence, health payers will not cover state-regulated psychedelic care. ORCHID is a public good — and only philanthropy can catalyze it.

2025 Complete

$60K raised for diligence, now completed. Key partnerships and IRB approval secured.

2026 Now

Recruitment, data collection, and medical-records linkage begins.

2027

ORCHID I findings published. Real policy-relevant cost data available.

2028

ORCHID II: long-term outcomes linked to health records; who benefits most.

2029

Full publication, policy briefs, presentations to decision-makers.

11 Voices from the field

The people who opened the door agree on what comes next.

Every state weighing public coverage of psychedelic care is running into the same wall: the fiscal case. Legislators want to know what it costs, what it saves, and whether the outcomes justify the spend. ORCHID is the kind of research infrastructure that can answer those questions with payer-grade evidence from Oregon and Colorado… If we want to move psychedelic care from an out-of-pocket service to a covered behavioral-health pathway, this is the evidence base that gets us there.

Sam ChapmanExecutive Director, Center for Psychedelic Policy · Campaign Manager, Oregon Psilocybin Services Ballot Measure 109 · Founding ED, Healing Advocacy Fund

This project is meaningful because it looks beyond whether psychedelic care can help and asks whether it can change healthcare utilization, costs, and access. Those are the questions that will determine whether this model reaches the people who need it most.

Seth Mehr, MDFounder, Cascade Psychedelic Medicine · Health & Safety Director, InnerTrek Psilocybin Service Center · Diplomate, American Board of Emergency Medicine

For state-regulated psychedelic care to become accessible beyond those who can pay out of pocket, we need evidence that payers, policymakers, and public programs can trust. ORCHID is the kind of research infrastructure that can help translate real-world psychedelic care into coverage, policy, and access.

Tamar ToddLecturer, Berkeley Law · Psychedelics Law and Drug Policy Reform Expert

ORCHID could be a turning point for the state-regulated model. By producing payer-grade evidence from Oregon and Colorado, it can help move psychedelic care from an out-of-pocket service toward a more equitable healthcare pathway.

Tom Eckert, MSFounder & ED, InnerTrek · Architect of Oregon Measure 109 · Founding Chair, Oregon Psilocybin Advisory Board · Founder, Sheri Eckert Foundation

Oregon and Colorado opened the door. ORCHID can determine what happens next.

Access for millions
or access for a few.

Fund

Close the funding gap

Fully implement both studies and produce decision-grade evidence.

Connect

Introductions welcome

Introductions to donors, payers, health plans, or research institutions with complementary interests.

Collaborate

Open to joint work

Let’s discuss joint work to make this project a reality and increase its impact.

Elliot Marseille · emarseille1@berkeley.edu Will Lucas · will.lucas@ucsf.edu Nathan Howard · nate@sherieckert.org

ORCHID · UC Berkeley · UCSF · Sheri Eckert Foundation · 2026